Extracellular matrix: the support for skin and filler

The extracellular matrix is the "scaffold" that occupies the space between the cells of the skin and tissues. It is not an empty space: it is an organized network of fibrous proteins and molecules that retain water, and it determines the firmness, elasticity and hydration of what we see on the outside. When we talk about skin quality, we are largely talking about the state of this matrix.

What is the matrix made of?

The main components are:

• Collagen (types I and III in the dermis), which gives strength and structure;
• Elastin, which lets the skin spring back after being stretched;
• Glycosaminoglycans, such as hyaluronic acid, which retain water and give volume and turgor;
• water and other signaling proteins.

Those who make and renew these components are mainly the fibroblasts, cells of the dermis. Over time, production falls and degradation rises, and the result is loss of firmness and volume.

Why does it matter in HOF?

Because almost everything we do interacts with the matrix.

• Hyaluronic acid injected as a filler is a stabilized version of a molecule that already exists in the matrix. It takes up space and attracts water, and the body integrates it into the tissues.
• Collagen biostimulators do not fill on their own: they trigger a response that leads fibroblasts to produce new matrix, in a process called neocollagenesis.
• Solar radiation, smoking and aging speed up the degradation of the matrix, which explains why skin and sun care remain relevant even with procedures.

Limits of the concept

The matrix is a dynamic system, affected by genetics, nutrition, hormones, habits and diseases. There is no "dose" that guarantees firmness, and promises of that kind are not compatible with responsible practice. The best argument is honesty: procedures act on certain components, with limited reach, and the result depends on each patient's response.

In Harmy

The app does not represent the extracellular matrix or skin quality. The projection shows the visual effect of volume in the marked areas, in ml, as an illustrative simulation, and the prompt forbids skin retouching. Therefore, skin texture and quality do not change in the simulation.

Also called: ECM, dermal matrix.